Season 4, Episode 1: She's Not There - Sookie returns to Bon Temps after a year in the fae world, finding much has changed. Jason is now a cop, and Bill is the King of Louisiana. Lafayette is exploring witchcraft, and Tara has fled to New Orleans. Jason is then locked in a freezer by the werepanthers. The episode concludes with Eric revealing he bought Sookie's house, declaring, "You are mine".

Season 4, Episode 2: You Smell Like Dinner - Eric confronts Marnie's coven, but Marnie casts a spell that wipes Eric's memory. Jason is held captive by the werepanthers of Hotshot, facing a grim fate. Sookie seeks help from Bill, now King of Louisiana, against Eric. The episode concludes with Sookie encountering a disoriented, amnesiac Eric on the road.

Season 4, Episode 3: If You Love Me, Why Am I Dyin'? - Sookie hides amnesiac Eric from the witches, enlisting Alcide's help. Jason is held captive, becoming a werepanther breeder. Bill sentences a vampire caught on video to the "true death". Eric, after drinking fairy blood, kills Sookie's fairy godmother.

Season 4, Episode 4: I'm Alive and On Fire - Sookie enlists Alcide to find a fae-blood drunk Eric. Jason escapes Hotshot, killing Felton. Marnie attempts to reverse the spell on Eric, but the witch Antonia possesses her and burns Pam's face. Bill discovers Portia is his descendant. The episode concludes with Marnie running away screaming.

Season 4, Episode 5: Me and the Devil - Tommy kills his abusive parents and seeks Sam's help to dispose of the bodies. Sookie comforts Eric, leading to a kiss after he expresses fear of hurting her. Bill imprisons Marnie, hoping to reverse her spells, while Pam accidentally reveals Eric's location to Bill. The episode concludes with Sookie and Eric kissing.

Season 4, Episode 6: I Wish I Was the Moon - Eric and Sookie are caught in flagrante delicto by Bill, who arrests Eric. Bill seeks the True Death for Eric, but Eric's remorseful plea sways him. Tommy shifts into Sam and ruins his life. Marnie becomes fully possessed by Antonia's spirit. Eric, freed by Bill, finds Sookie, and they have sex in the woods.

Season 4, Episode 7: Cold Grey Light of Dawn - Marnie, now fully possessed by Antonia, gains power, leading Bill to order vampires to silver themselves for protection. Eric and Sookie's relationship intensifies. Luis, controlled by Antonia, attacks Bill and then stakes himself. Jessica escapes her silver chains as dawn breaks.

Season 4, Episode 8: Spellbound - Bill meets with Antonia to negotiate peace, but the encounter erupts into a chaotic battle between vampires and witches. Sookie is shot amidst the fighting, and Alcide rescues her. Eric falls under Marnie/Antonia's control. Jessica and Jason share a moment, breaking Marnie's spell on her. The episode concludes with Antonia looming over a now-enslaved Eric.

Season 4, Episode 9: Let's Get Out of Here - Sookie recovers from being shot, dreaming of a relationship with both Bill and Eric. Lafayette, possessed, kidnaps Arlene's baby. Debbie, fueled by V, plots against Sookie. Eric, under Marnie's spell, is set to attack the vampire festival. The episode concludes with preparations for a vampire-witch confrontation.

Season 4, Episode 10: Burning Down the House - Sookie uses her fairy powers to break Marnie's spell on Eric. Tommy finally dies after an attack, leading Sam on a path for revenge. Bill plans to bomb the Moon Goddess Emporium, despite Tara being inside. The episode ends with the vampires preparing to attack the Emporium.

Season 4, Episode 11: Soul of Fire - Sookie uses her fairy powers to break Marnie's spell, but Marnie retaliates. Jesus and Lafayette separate Antonia from Marnie, weakening her. Eric rips Roy's heart out. Alcide kills Marcus after he attacks Sam. Bill shoots Marnie, but her spirit possesses Lafayette.

Season 4, Episode 12: And When I Die - Marnie, possessing Lafayette, kills Jesus to harness his magic. Sookie, Tara, and Holly confront Marnie, who is about to burn Bill and Eric. Sookie ends Marnie's threat with help from Gran's spirit. Debbie shoots at Sookie, but Tara takes the bullet and seemingly dies. The episode concludes with Steve Newlin's return as a vampire and the revelation of Russell Edgington's escape.