On Rizzoli & Isles, Boston detective Jane Rizzoli and medical examiner Maura Isles are complete opposites and good friends who solve crimes and bust some of Boston's most notorious criminals. Jane, the only female detective in Boston's homicide division, is a tough and gutsy cop who doesn't let her guard down (except with Maura), dodges her overprotective mother, and is better at basketball than her brother. Maura, meanwhile, is usually more comfortable among the dead than the living. She is always impeccably dressed in designer duds with a steady, sometimes icy temperament. Jane and Maura often find themselves working together as both use their brilliant minds and expertise to figure out the "who done it" as well as the "how done it" of Boston's most complex cases.