Emily Watson

as Valya Harkonnen

Olivia Williams

as Tula Harkonnen

Chloe Lea

as Sister Lila

Barbara Marten

as Sister Avila

Jade Anouka

as Sister Theodosia

Aoife Hinds

as Sister Emeline

Faoileann Cunningham

as Sister Jen

Jodhi May

as Empress Natalya Arat Corrino

Travis Fimmel

as Desmond Hart

Sarah-Sofie Boussnina

as Princess Ynez Corrino