Noah Wyle

as Dr. Michael "Robby" Robinavitch

Supriya Ganesh

as Dr. Samira Mohan

Fiona Dourif

as Dr. Cassie "Cass" McKay

Taylor Dearden

as Dr. Melissa "Mel" King

Isa Briones

as Dr. Trinity Santos

Gerran Howell

as Dr. Dennis Whitaker

Shabana Azeez

as Dr. Victoria Javadi

Katherine LaNasa

as Dana Evans

Patrick Ball

as Dr. Frank Langdon

Tracy Ifeachor

as Dr. Heather Collins