Jeremy Irons

as Rodrigo Borgia

François Arnaud

as Cesare Borgia

Holliday Grainger

as Lucrezia Borgia

Sean Harris

as Micheletto

Joanne Whalley

as Vanozza Cattaneo

Lotte Verbeek

as Giulia Farnese

Colm Feore

as Cardinal Della Rovere

David Oakes

as Juan Borgia

Aidan Alexander

as Joffre Borgia

Simon McBurney

as Johannes Burchart