Set in modern-day Berlin, Spides follows Nora, a young woman who wakes from a coma without any memory of her previous life after taking a mysterious drug; local police detective David Leonhart and his partner Nique Navar are hunting down that drug in relation to dozens of missing teens. When Nora sets out to discover what happened to her, she begins to unravel a conspiracy of aliens who are using a synthetic drug to infiltrate humans to use as host bodies. The more truth Nora uncovers, the more of her own dark secret is revealed: she is the key to the invasion she is fighting.