Tia and Tamera Mowry play twins who were separated at birth and by chance meet each other in a shopping mall. Ray Campbell, Tamera's adopted father, is very different from Tia's adopted mother, Lisa Landry, but the twins don't want to be separated so Ray and Lisa end up living together. The series often focuses on the trouble the twins get into due to their identical appearance and the love-hate relationship between Lisa and Ray.