Single Black Female follows Monica, who's reeling from the death of her beloved father and a difficult breakup, ready to move forward with her life as she tries to land the new hosting job for an afternoon talk show. When the station hires her a new assistant, Simone, the two quickly become close friends as Simone moves in next door and completely immerses herself in Monica's life. But underneath her sweet exterior, Simone harbours a dark secret and as time goes on cracks in her façade begin to appear. Monica decides to sever ties once and for all with Simone, but Simone has other plans and is determined to take over Monica's life for good.