Roseanne Barr

as Roseanne Conner

John Goodman

as Dan Conner

Laurie Metcalf

as Jackie Harris

Sara Gilbert

as Darlene Conner

Michael Fishman

as D.J. Conner

Lecy Goranson

as Becky Conner

Sarah Chalke

as Becky Conner

Ames McNamara

as Mark Conner-Healy

Emma Kenney

as Harris Conner-Healy

Jayden Rey

as Mary Conner