Ish and his family have relocated to Canton, Ohio, home of the Pro Football Hall of Fame, where Ish can learn more about his destiny as a Guardian. It seems that NFL Football is safe once again, until the emergence of a new master villain, Wild Card, who threatens to destroy not only the NFL, but the world itself. With the escalation of this conflict, Ish heightens his own training, skills, and powers, but will be joined by a new band of allies, who will become known as The League of Guardians on "The NFL Rush Zone".