Set in the Leimert Park section of Los Angeles, Moesha follows the life of a happy-go-lucky family through the eyes of a typical teenage girl. Her father, Frank, a Saturn car salesman, has remarried Dee, a teacher at her school, much to Moesha's dismay. As Dee makes real headway becoming a mother to Moesha's little brother, Myles, Moesha's fond memories of her real mother have inhibited her from opening up completely to Dee.