Daniel Sharman

as Lorenzo de' Medici

Aurora Ruffino

as Bianca de' Medici

Sebastian De Souza

as Sandro Botticelli

Alessandra Mastronardi

as Lucrezia Donati

Synnøve Karlsen

as Clarice Orsini

Annabel Scholey

as Contessina de' Medici

Sarah Parish

as Lucrezia de' Medici (older)

Callum Blake

as Carlo de' Medici

Bradley James

as Giuliano de' Medici

Guido Caprino

as Marco Bello