Lab Rats introduces Leo just as he settles into the high-tech home he shares with his inventor stepdad, Donald Davenport, his mom, Tasha, and Eddy, the "smart house" computer. There he discovers a secret underground lab with three experiments, super-human teens: Adam the strong one, Bree the fast one and Chase the smart one. The trio, eager to leave their confines, convinces Leo and his parents to let them join him at school where they try to fit in while trying to manage their unpredictable bionic strengths. Along the way, they help Leo build self confidence while he figures out a way to keep their bionic abilities a secret from the world.