The pure and innocent Nanako Matsutaka is a seemingly normal girl with a normal student life, except that she's enrolled in a Pervert Physiology Course run by the depraved Professor Meshiya! Being a naïve girl with no sexual experience and a disdain for anything perverted, Nanako is at the bottom of her class. As she attempts to avoid flunking out of the course, Nanako works alongside her classmates in order to complete her various unorthodox assignments from Professor Meshiya.