Ellen Pompeo

as Dr. Meredith Grey

James Pickens, Jr.

as Dr. Richard Webber

Chandra Wilson

as Dr. Miranda Bailey

Kevin McKidd

as Dr. Owen Hunt

Justin Chambers

as Dr. Alex Karev

Jesse Williams

as Dr. Jackson Avery

Camilla Luddington

as Dr. Jo Wilson

Patrick Dempsey

as Dr. Derek Shepherd

Sara Ramírez

as Dr. Calliope "Callie" Torres

Sandra Oh

as Dr. Cristina Yang