Doctor Henry Morgan, New York City's star medical examiner, has a secret. He doesn't just study the dead to solve criminal cases, he does it to solve the mystery that has eluded him for 200 years - the answer to his own inexplicable immortality. This long life has given Henry remarkable observation skills which impresses his new partner, Detective Jo Martinez. Each week, a new case and their budding friendship will reveal layers of Henry's long and colorful past. Only his best friend and confidant, Abe knows Henry's secret.